Reference Citation	Study Type	Subjects	Age (y)	Treatment	Results
[12]	Open label	8 women, 2 men	Mean not reported; range, 26–65	Desipramine	7 subjects much improveda; 2 subjects minimally improved; 1 dropout
[13]	Open label	8 women, 5 men	Mean, 71.1; range, 61–78	Nortriptyline	Mean HDRS scores decreased 67.9%; no dropouts
[14]	Open label	17 women, 5 men	Mean, 63.5; range, 45–83	Bupropion SR	Mean HDRS scores decreased 54%; 8 dropouts
[15]b	Randomized controlled	58 women, 22 men	Mean range for 4 groups, 63.2–69.5	Nortriptyline vs. placebo vs. NTP+IPT or PLA+IPT	NTP statistically significant compared to PLA; NTP+IPT group had lowest attrition rate

HDRS = Hamilton Depression Rating Scale; IPT = interpersonal psychotherapy; NTP = nortriptyline; PLA = placebo; SR = sustained release.

aImprovement based on the Clinical Global Impression (CGI) rating after review of the decline in HDRS score.

bSee text for details.

References

12. Jacobs SC, Nelson JC, Zisook S: Treating depressions of bereavement with antidepressants. A pilot study. Psychiatr Clin North Am 10 (3): 501-10, 1987.  [PUBMED Abstract]
    
    
13. Pasternak RE, Reynolds CF 3rd, Schlernitzauer M, et al.: Acute open-trial nortriptyline therapy of bereavement-related depression in late life. J Clin Psychiatry 52 (7): 307-10, 1991.  [PUBMED Abstract]
    
    
14. Zisook S, Shuchter SR, Pedrelli P, et al.: Bupropion sustained release for bereavement: results of an open trial. J Clin Psychiatry 62 (4): 227-30, 2001.  [PUBMED Abstract]
    
    
15. Reynolds CF 3rd, Miller MD, Pasternak RE, et al.: Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy. Am J Psychiatry 156 (2): 202-8, 1999.  [PUBMED Abstract]