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Table 1. Major Histopathological Categories of Non-Hodgkin Lymphoma in
Children and Adolescentsa
|
Category (WHO Classification/ Updated REAL)
|
Category (Working Formulation)
|
Immuno-phenotype
|
Clinical Presentation
|
Chromosome Translocation
|
Genes Affected
|
| Burkitt and Burkitt-like lymphomas |
ML small noncleaved cell |
Mature B cell |
Intra-abdominal (sporadic), head and neck (non-jaw, sporadic), jaw (endemic) |
t(8;14)(q24 q32), t(2;8)(p11;q24), t(8;22)(q24; q11) |
C-MYC, IGH, IGK, IGL |
| Diffuse large B-cell
lymphoma |
ML large cell |
Mature B cell; maybe CD30+ |
Nodal, abdomen, bone, primary CNS, mediastinal |
No consistent cytogenetic abnormality identified |
|
| Lymphoblastic lymphoma, precursor T-cell/leukemia, or precursor B-cell lymphoma |
Lymphoblastic convoluted and
non-convoluted
|
Pre-T cell |
Mediastinal, bone marrow |
MTS1/p16ink4a Deletion TAL1 t(1;14)(p34; q11), t(11;14)(p13;q11) |
TAL1, TCRAO, RHOMB1, HOX11
|
| Pre-B cell |
Skin, bone |
| Anaplastic
large cell
lymphoma,
systemic |
ML immunoblastic or ML large |
CD30+ (Ki-1+) |
Variable, but systemic symptoms often prominent |
t(2;5)(p23; q35) |
ALK, NPM |
| T cell or null cell |
| Anaplastic
large cell
lymphoma,
cutaneous
|
|
CD30+ (Ki-usually) |
Skin only; single or multiple lesions |
Lacks t(2;5) |
|
| T cell |
|
CNS = central nervous system; ML = malignant lymphoma.
|
|
aAdapted from Percy et al.[2]
|
References
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Percy CL, Smith MA, Linet M, et al.: Lymphomas and reticuloendothelial neoplasms. In: Ries LA, Smith MA, Gurney JG, et al., eds.: Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. Bethesda, Md: National Cancer Institute, SEER Program, 1999. NIH Pub.No. 99-4649., pp 35-50. Also available online. Last accessed July 16, 2009.
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