The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information

Added Arico et al. as reference 14.

Added text to state that approximately 20% of ALL cases arising in children with Down syndrome have somatically acquired JAK2 mutations, a finding that is uncommon among younger children with ALL but that is observed in a subset of primarily older children and adolescents with high-risk B-precursor ALL (cited Bercovich et al. as reference 15, Gaikwad et al. as reference 16, Kearney et al. as reference 17, and Mullighan et al. as reference 18).

Untreated Childhood Acute Lymphoblastic Leukemia

Added Jansen et al. as reference 60.

Added text to state that controversy exists about whether patients who receive dexamethasone or prednisone are at higher risk for neurocognitive disturbances, although long-term neurocognitive testing did not demonstrate any meaningful differences in cognitive functioning based on corticosteroid randomization (cited Kadan-Lottick et al. as reference 65).

Recurrent Childhood Acute Lymphoblastic Leukemia

Added text to state that in T-cell depleted HD CD34 haploidentical transplants, patients receiving maternal stem cells and/or allogeneic cells from an NK-reactive donor, may have a better outcome than those who receive paternal stem cells (cited Stern et al. as reference 51 and level of evidence 3iiA).

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