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Cediranib for Androgen-Independent Prostate Cancer
Untitled Document
Name of the Trial
Phase II Study of AZD2171 in Patients With Metastatic Androgen-Independent
Prostate Cancer (NCI-07-C-0059). See the protocol
summary.
Principal Investigators
Dr. William Dahut and Dr. William Figg (Protocol Chair), NCI Center for Cancer
Research.
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Dr. William Dahut
Principal Investigator |
Why This Trial Is Important
Advanced prostate cancer is often dependent upon male hormones (androgens)
for continued growth and may initially respond to anti-androgen therapy. Unfortunately,
however, prostate cancer growth ultimately becomes androgen-independent. Treatment
with the chemotherapy drug docetaxel may help men with androgen-independent
prostate cancer survive longer, but, if the cancer becomes resistant to docetaxel,
there currently are no other proven effective treatment options.
One strategy being tested for treating metastatic, androgen-independent prostate
cancer is to block the blood supply that feeds the tumors. A large body of research
indicates that solid tumors need to develop new blood vessels (a process called
tumor angiogenesis) in order to keep growing and that attacking the tumor blood
supply may inhibit further growth and spread. Some studies suggest that metastatic
prostate cancer may be especially dependent on tumor angiogenesis.
A drug called cediranib blocks the action of vascular endothelial growth factor
(VEGF), a protein that plays a crucial role in tumor angiogenesis, by attaching
to VEGF receptors on cancer cells. Cediranib treatment, therefore, may be able
to block prostate tumor angiogenesis and inhibit prostate tumor growth.
In this trial, men with metastatic, androgen-independent prostate cancer whose
cancer has continued to progress on docetaxel will take oral
cediranib daily. Treatment will continue for those patients whose tumors do
not progress and who do not suffer unacceptable side effects. Doctors want to
see if cediranib can help delay the progression of cancer in these patients.
"There are a number of drugs that block the action of VEGF being tested
in metastatic, androgen-independent prostate cancer, but each drug works differently"
said Dr. Dahut. "Cediranib looks to be a promising agent because it blocks
more VEGF receptors than other drugs in the class, potentially making it a more
effective inhibitor of tumor angiogenesis."
For More Information
See the list of
eligibility criteria and contact information or call the NCI Clinical Trials
Referral Office at 1-888-NCI-1937. The call is toll free and confidential.
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