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1. NCI Statement on Breast Cancer Screening
(Posted: 11/16/2009) - NCI appreciates the U.S. Preventive Services Task Force's careful review and analysis of the evidence regarding breast cancer screening for women at average risk. The take-away message is that each woman needs to consider her individual benefits and risks and discuss them with her health care provider before making a decision on when to start screening mammography and how often to get
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2. Nicotine Patch - Nicotine Lozenge Combination Works Best For Smoking Cessation
(Posted: 11/02/2009) - In the largest study to date comparing smoking cessation therapies, the use of the nicotine lozenge in combination with the nicotine patch provided the greatest benefit for smokers trying to quit, resulting in over a two-fold better smoking cessation outcome 6 months after quitting compared to smokers who received placebo medication. The study also showed that this combination improved initial cessation and end of treatment quit rates compared to using just one therapy.
3. News Note: Comparative Effectiveness Grants in Genomic and Personalized Medicine Announced
(Posted: 10/21/2009) - As part of the American Recovery and Reinvestment Act of 2009, the National Cancer Institute, part of NIH, recently funded seven research and research infrastructure Grand Opportunities, or GO grants. The awards were for Comparative Effectiveness Research (CER) in genomic and personalized medicine (GPM).
4. News Note: Strategy Sensitizes Tumors while Protecting Normal Tissues in Mice from Radiation Damage
(Posted: 10/21/2009) - Researchers at NCI and other institutes have developed a method that protects healthy tissues from the damaging effects of radiation treatment, while at the same time delaying tumor growth.
5. Centralized Review Process Markedly Expedites Approval of Cancer Clinical Trials
(Posted: 10/19/2009) - A Central Institutional Review Board (CIRB) for cancer clinical trials that was created by the National Cancer Institute (NCI), part of the National Institutes of Health, in 2001 helps trials start more quickly (just over a month faster, on average) and thus expedite the time from concept to completion of crucial investigational research according to a new finding.
6. News Note: Gene Therapy Method Slows Tumor Growth in Mice
(Posted: 10/09/2009) - NCI researchers have developed a novel method in mice of delivering genes to cancer cells, that when expressed, promote cell death. These genes, known as suicide genes, cause a cell to kill itself through a process known as apoptosis. The new technique uses the survivin gene promoter to express the suicide gene and induce apoptosis in cancer cells. This method of gene delivery effectively targeted tumor cells with a minimum effect on normal cells.
7. Consortium of Researchers Discover Retroviral Link to Chronic Fatigue Syndrome
(Posted: 10/08/2009) - Scientists have discovered a potential retroviral link to chronic fatigue syndrome, known as CFS, a debilitating disease that affects millions of people in the United States. Researchers from the Whittemore Peterson Institute (WPI), located at the University of Nevada, Reno, the NCI, and the Cleveland Clinic, report this finding online Oct. 8, 2009, issue of Science.
8. Prostate Tumors Can Change the Function of Immune Cells in Mice
(Posted: 10/07/2009) - Researchers have discovered that prostate tumors in mice can cause immune cells known as CD8+ T cells to change their function from cells that have antitumor activity to cells that suppress immune responses. This finding, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, has important implications for the design of immune-based therapies for cancer.
9. Short Strand of RNA May Help Predict Survival and Response to Treatment for Patients with Liver Cancer
(Posted: 10/07/2009) - A small RNA molecule, known as a microRNA, may help physicians identify liver cancer patients who, in spite of their poor prognosis, could respond well to treatment with a biological agent called interferon. The finding, by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health, and their partners at Fudan University, Shanghai, and the University of Hong Kong in China and at Ohio State University, Columbus, appeared in the Oct. 8, 2009, issue of The New England Journal of Medicine.
10. Gene Mutation Linked to Type of Childhood Cancer
(Posted: 10/05/2009) - Researchers have identified a gene that may play a role in the growth and spread of a childhood cancer called rhabdomyosarcoma, which develops in the body's soft tissues. The finding has revealed a potential new target for the treatment of this disease.
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