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1. Researchers Develop a Method to Evaluate Variations Identified in Breast Cancer Susceptibility Genes
(Posted: 07/06/2008) - Using mouse embryonic stem cells, researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have developed a new method to evaluate which mutations, or changes, in a gene known to increase breast cancer susceptibility, may lead to cancer.
2. How to Move Cancer Research Forward: Public/Private Partnerships - a NCI Science Writer's Seminar
(Posted: 07/01/2008) - Please join us for a science writers' seminar to discuss public/private partnerships in cancer research. Among the topics discussed will be working with industry to develop new drugs; cancer vaccine development and business barriers; working with small businesses to develop new technologies to catch cancer in its earliest stages; and intellectual property rights and technology transfer issues related to new genetic tests. The seminar will be in a classroom setting with ample time for Q&A and interaction during the talks.
3. Yeast-Based Vaccine Induces Immune Responses and Reduces Tumor Size in Mice
(Posted: 07/01/2008) - Scientists have found that vaccination with a heat-killed, nontoxic yeast that is genetically engineered to manufacture a common tumor protein can induce specific and repeated anti-tumor immune responses in mice. Vaccination extends overall survival and reduces tumor size in mice that have been injected with cancer cells displaying the same protein that was engineered into the yeast.
4. Study Shows That Small Protein Can Broaden Immune Response in Humans
(Posted: 06/23/2008) - Treating cancer patients with interleukin-7, a small protein that can stimulate the immune system, leads to an increase in lymphocytes which are key to the production of effective immune responses in the body, according to a new study by researchers at the NCI.
5. Blocking a Single Protein Proves Toxic to Myeloma Cells in Laboratory Studies
(Posted: 06/23/2008) - Researchers have found that cells from a blood-borne cancer called multiple myeloma rely on the activity of a single protein, IRF4, for the activation of a wide range of genes responsible for cell survival and spread. Blocking the production of this protein can be strikingly effective in eliminating cancer cells in laboratory models of multiple myeloma.
6. Biennial Cancer Survivorship Research Conference Aims to Improve Quality of Life for Cancer Survivors and Their Families
(Posted: 06/20/2008) - According to research presented today, many older cancer patients can tolerate more aggressive treatment than they typically receive, and age, income, and education all can impact the physical health of cancer caregivers. More than 400 of the nation's leading experts in cancer survivorship have convened for Cancer Survivorship Research: Mapping the New Challenges, where these and other findings about living with and beyond cancer are being presented this week.
7. NCI Scientists Visualize Gene Regulation in Living Cells
(Posted: 05/22/2008) - A research team led by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has applied advanced imaging methods and computer simulations to be able to glance at the regulation of a cancer-related gene in a living cell.
8. New Method Proposed for Determining Which Patients Should Get Treatment for Colorectal Cancer
(Posted: 05/16/2008) - A new study being presented at the American Society of Clinical Oncology meeting in Chicago (Abstract #4020), may change treatment practice in about 25 percent of patients with colon cancer and is the basis for proposed changes to the way colorectal cancers will be staged.
9. Researchers Find that a Small Molecule Can Activate an Important Cancer Suppressor Gene
(Posted: 05/01/2008) - By activating a cancer suppressor gene, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health. This activation of the p53 gene leads to cellular senescence, a process by which cells lose their ability to grow and divide. An opportunity for new genetic mutations occurs each time a cell divides, so limiting the number of cell divisions in a cancer cell inhibits tumor progression.
10. Mouse Studies Identify Gene that May Influence Metastasis Risk in Breast Cancer
(Posted: 04/21/2008) - Researchers have identified a pattern of gene activity in mice that may help to predict individual risk for breast cancer metastasis and survival in humans. A single gene called bromodomain 4 (Brd4) regulates the expression of this pattern, also called a signature. The researchers found that one result of this Brd4 regulation is the suppression of tumor growth and metastasis in a mouse model of cancer.
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